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Tiny stamps for tiny sensors (MIT)
Advances in microchip technology may someday enable clinicians to perform
tests for hundreds of diseases — sifting out specific molecules, such as early
stage cancer cells — from just one drop of blood. But fabricating such “lab-
on-a-chip” designs — tiny, integrated diagonistic sensor arrays on surfaces as
small as a square centimeter — is a technically challenging, time-consuming
and expensive feat.
Now, an MIT researcher — together with colleagues at the University of
Illinois at Urbana-Champaign — has come up with a simple, precise and
reproducible technique that cuts the time and cost of fabricating such
sensors. Nicholas Fang, associate professor of mechanical engineering, has
developed an engraving technique that etches tiny, nano-sized patterns on
metallic surfaces using a small, voltage-activated stamp made out of glass.
Fang says the engravings, made of tiny dots smaller than one-hundredth the
width of a human hair, act as optical antennae that can identify a single
molecule by picking up on its specific wavelength.
“If you are able to create an optical antenna with precise dimensions … you
can use them to report traffic on the molecular scale,” Fang says.
The researchers reported the new fabrication process in the Sept. ...